Article
Basal detachment of the epidermis using dispase: tissue spatial organization and fate of integrin alpha 6 beta 4 and hemidesmosomes.
The Journal of investigative dermatology - 1 Jan 1994
Poumay Y, Roland I H, Leclercq-Smekens M, Leloup R
Abstract excerpt
Dispase has been utilized to produce basal detachment of the epidermis of human skin biopsies and to study the consequences induced afterwards during incubations of the detached tissue. Spatial reorganization of the epidermis is observed under these conditions and is characterized by disappearanc...
Topics
- Adult
- Antigens, Surface
- Basement Membrane
- Cell Communication
- Cell Movement
- Cells, Cultured
- Cytoplasm
- Desmosomes
- Endopeptidases
- Epidermal Cells
- Epidermis
- Fluorescent Antibody Technique
- Humans
- Integrin alpha6beta4
- Integrins
- Microscopy, Electron
- Phenotype