Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.

doi:10.1038/clpt.1990.46

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Article

Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.

Clinical pharmacology and therapeutics - 1 Mar 1990

Veronese M E, Miners J O, Randles D, Gregov D, Birkett D J

Abstract excerpt

The present study has validated kinetically a convenient method to measure tolbutamide hydroxylation capacity in human beings by use of urinary metabolic ratios. The known in vivo and in vitro inhibitory properties of sulfaphenazole were used to convert control phase subjects to phenotypically "p...

Topics

Administration, Oral
Adult
Chromatography
Female
Half-Life
Humans
Hydroxylation
Male
Phenotype
Random Allocation
Sulfaphenazole
Tolbutamide

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