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Article

Prevalence and clinical correlations of MLL gene rearrangements in AML- M4/5

1 Dec 1994

Abstract excerpt

Rearrangements of the human trithorax gene (MLL, HRX, Htrx-1, All-1) were studied by Southern blotting in blast cells stored at presentation from 65 adults with de novo acute myelomonocytic (AML-M4) and acute monocytic leukemia (AML-M5). MLL rearrangements were demonstrated in 15 (23%) cases, including eight patients in whom karyotype analysis had failed to detect abnormalities of chromosome band 11q23. The...

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PMID: 7949133
DOI: 10.1182/blood.v84.11.3776.bloodjournal84113776

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