Article
Specific rearrangements of human papillomavirus DNA provide molecular evidence for genetic heterogeneity of primary cervical cancers, recurrencies, and lymph node metastases in two patients.
Gynecologic oncology - 1 Nov 1993
Girardi F, Pickel H, Beyer-Finkler E, Pfister H
Abstract excerpt
Two different characteristic patterns of human papilloma virus (HPV) type 16 DNA were found by Southern blot hybridization in four pelvic and paraaortic lymph node metastases in a patient with FIGO stage IIIb cervical cancer. Both patterns added up to give the HPV 16 DNA pattern of the primary tu...
Topics
- Adult
- Aged
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- DNA, Viral
- Female
- Gene Rearrangement
- Genetic Variation
- Humans
- Lymphatic Metastasis
- Papillomaviridae
- Polymerase Chain Reaction
- Uterine Cervical Neoplasms
- Vaginal Neoplasms