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Article

Highly polymorphic repeat marker within the beta-amyloid precursor protein gene.

Human genetics - 1 Jan 1994

Zappata S, Petersen M B, König U, Blaschak J, Chakravarti A, Tassone F, Serra A, Antonarakis S E, Brahe C

Abstract excerpt

We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the beta-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivs1, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

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Source

Identifiers

PMID: 8270262
DOI: 10.1007/BF00218922

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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