Article
Highly polymorphic repeat marker within the beta-amyloid precursor protein gene.
Human genetics - 1 Jan 1994
Zappata S, Petersen M B, König U, Blaschak J, Chakravarti A, Tassone F, Serra A, Antonarakis S E, Brahe C
Abstract excerpt
We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the beta-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivs1, we detected 13 alleles in the CEPH family members (heterozygo...
Topics
- Alleles
- Amyloid beta-Protein Precursor
- Base Sequence
- Chromosomes, Human, Pair 21
- DNA
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Genetic Markers
- Humans
- Introns
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid