Article
Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region.
Pharmacogenetics - 1 Feb 1998
Durocher F, Morissette J, Simard J
Abstract excerpt
The first rate-limiting step in the biosynthesis of all mammalian steroid hormones is the conversion of cholesterol to pregnenolone by the cholesterol side-chain cleavage enzyme, P450scc. The human CYP11A1 gene, encoding the mitochondrial P450scc, has been previously assigned by in situ hybridiza...
Topics
- Alleles
- Base Sequence
- Cholesterol Side-Chain Cleavage Enzyme
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Cytochrome P-450 CYP1A1
- DNA Primers
- Female
- Genetic Linkage
- Genotype
- Humans
- Male