Article
High-resolution physical mapping of a 6.7-Mb YAC contig spanning a region critical for the monosomy 21 phenotype in 21q21.3-q22.1.
Genomics - 1 Jul 1997
Orti R, Mégarbane A, Maunoury C, Van Broeckhoven C, Sinet P M, Delabar J M
Abstract excerpt
Deletion of genes from the chromosome 21 region between APP and SOD1 is a potential cause of some of the major phenotypic features of monosomy 21 patients. Fine physical mapping helps identify potential candidate genes. After selecting nonchimeric YACs by FISH analysis, we determined their marker...
Topics
- Abnormalities, Multiple
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 21
- Cloning, Molecular
- Cosmids
- DNA Primers
- Genetic Markers
- Humans
- In Situ Hybridization, Fluorescence
- Phenotype
- Polymerase Chain Reaction
- Restriction Mapping
- Sequence Tagged Sites
- Telomere