Article
Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.
Human genetics - 1 Jan 1994
Volz A, Weiss E, Trowsdale J, Ziegler A
Abstract excerpt
An expressed beta-tubulin gene (TUBB) has previously been localized to chromosome region 6pter-p21 in man. By using a panel of deletion mutant cell lines and radiation-reduced hybrids containing fragments of chromosome 6, the TUBB locus could be mapped to the HLA class I region at 6p21.3. A long...
Topics
- Animals
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Ciliary Motility Disorders
- Cricetinae
- DNA Probes
- Electrophoresis, Agar Gel
- HLA Antigens
- HLA-C Antigens
- Humans
- Hybrid Cells
- Microtubules
- Mutation
- Polymerase Chain Reaction
- Restriction Mapping