Amplification of the c-myc Proto-Oncogene in Soft Tissue Sarcomas

Abstract excerpt

Soft tissue sarcoma fresh specimens from 23 patients were screened for genetic abnormalities of 3 cellular oncogenes, i.e., c-myc and c-myb and c-Ha-ras. Southern blot hybridization analysis demonstrated amplification of the c-myc gene (4- to 8-fold) in 7 cases, i.e., 3 malignant fibrous histiocytomas, 1 liposarcoma, 1 fibrosarcoma, 1 lymphoma of the soft tissues and 1 synovial sarcoma. Amplification of the c-myc...

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