Article
Human ferritin H-chains can be obtained in non-assembled stable forms which have ferroxidase activity.
FEBS letters - 27 Dec 1993
Levi S, Santambrogio P, Albertini A, Arosio P
Abstract excerpt
We found conditions to obtain the Leu-169-->Arg mutant of human ferritin H chain in a stable and non-assembled state. The protein obtained is an oligomer of subunits with a high degree of structured conformation, and when concentrated it re-assembles into ferritin cages. Functional studies showed that (i) it promotes iron oxidation like the assembled ferritin, but at slower rate, (ii) it is readily precipitated...
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