Human ferritin H-chains can be obtained in non-assembled stable forms which have ferroxidase activity.

doi:10.1016/0014-5793(93)80826-g

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Article

Human ferritin H-chains can be obtained in non-assembled stable forms which have ferroxidase activity.

FEBS letters - 27 Dec 1993

Levi S, Santambrogio P, Albertini A, Arosio P

Abstract excerpt

We found conditions to obtain the Leu-169-->Arg mutant of human ferritin H chain in a stable and non-assembled state. The protein obtained is an oligomer of subunits with a high degree of structured conformation, and when concentrated it re-assembles into ferritin cages. Functional studies showed...

Topics

Arginine
Ceruloplasmin
Ferritins
Humans
Leucine
Mutation
Oxidation-Reduction
Protein Conformation
Protein Denaturation

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