Article
Loop mutations can cause a substantial conformational change in the carboxy terminus of the ferritin protein.
Journal of molecular biology - 20 Sept 1992
Jappelli R, Luzzago A, Tataseo P, Pernice I, Cesareni G
Abstract excerpt
Although some protein folding theories sustain that the peptides (loops) that connect elements of more compact secondary structure may be important in the folding process, most of the data accumulated until now seems to contradict this notion. To approach this problem we have isolated and characterized a number of mutants in which the amino acid sequence of the peptide that connects helix D and helix E in the...
Topics
- Amino Acid Sequence
- DNA
- Ferritins
- Molecular Sequence Data
- Mutation
- Phenotype
- Proline
- Protein Folding
- Solubility