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Article

Cooperativity of mutational effects within a six amino acid residues substitution that induces a major conformational change in human H ferritin.

Biochemical and biophysical research communications - 18 Sept 1998

Jappelli R, Cesareni G

Abstract excerpt

Ferritin is an iron-storage protein composed of 24 polypeptide chains which assemble into a hollow shell. Previously, we have shown that a multisubstituted ferritin mutant containing the peptide ESVWNP in place of the wild-type sequence GAPESG in a short exposed loop directs the synthesis of a product that assembles in a conformation remarkably different from that of the normal molecule. We have further...

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Identifiers

PMID: 9753631
DOI: 10.1006/bbrc.1998.9317

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