Structural and immunologic analysis of gene triplications in the Ig heavy chain constant region locus.

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Article

Structural and immunologic analysis of gene triplications in the Ig heavy chain constant region locus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1994

Brusco A, Cariota U, Bottaro A, Boccazzi C, Plebani A, Ugazio A G, Galanello R, van Leeuwen A M, DeLange G G, Depelchin S

Abstract excerpt

The Ig H chain C region is a multigene family often involved in genomic rearrangements leading to deleted and duplicated haplotypes, most probably through unequal crossing over between homologous regions within the locus. The frequency of these haplotypes in Italy is around 2.7% each. Using PFGE...

Topics

Gene Deletion
Gene Rearrangement
Genes, Immunoglobulin
Genotype
Haplotypes
Humans
Immunoglobulin Class Switching
Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Multigene Family
Pedigree

Source

Open in PubMed

Identifiers

PMID: 8254186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8254186-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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