The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila.

doi:10.1371/journal.pone.0076498

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Article

The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila.

PloS one - 1 Jan 2013

Mirzoyan Zhasmine, Pandur Petra

Abstract excerpt

Drosophila heart development is an invaluable system to study the orchestrated action of numerous factors that govern cardiogenesis. Cardiac progenitors arise within specific dorsal mesodermal regions that are under the influence of temporally coordinated actions of multiple signaling pathways. The Drosophila Iroquois complex (Iro-C) consists of the three homeobox transcription factors araucan (ara), caupolican...

Topics

Animals
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation, Developmental
Heart
Homeodomain Proteins
Mesoderm
Mutation
Myocardium
Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24086746
DOI: 10.1371/journal.pone.0076498
PMCID: PMC3781054

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