Article
Familial co-segregation of the elastin phenotype in skin fibroblasts from Hutchinson-Gilford progeria.
Mechanisms of ageing and development - 15 Aug 1993
Giro M, Davidson J M
Abstract excerpt
Elastin and type IV collagen production are markedly elevated in fibroblasts derived from the skin of patients with Hutchinson-Gilford progeria (HGP). Fibroblasts from three affected children and their parents were compared to normal human skin fibroblasts with respect to elastin production as a function of different concentrations of calf serum and the cytokines, transforming growth factor-beta and basic...
Topics
- Adolescent
- Adult
- Cells, Cultured
- Child
- Elastin
- Female
- Fibroblast Growth Factor 2
- Fibroblasts
- Humans
- Infant
- Male
- Phenotype