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Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations?

Medical sciences (Basel, Switzerland) - 15 Dec 2025

Erokhina Mariia A, Vorotelyak Ekaterina A, Vasiliev Andrey V, Abdyev Vepa K

Abstract excerpt

Children with Hutchinson-Gilford progeria syndrome (HGPS) are born without height and weight abnormalities, and postnatal development is delayed from two months of age. The pathophysiological manifestations of HGPS can be categorized into the three tissue systems that are primarily affected: bone and cartilage, the smooth muscular layer of the vasculature, and the dermis layer. To understand the biology of the...

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Identifiers

PMID: 41440552
DOI: 10.3390/medsci13040321
PMCID: PMC12734546

Genes

LMNA

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