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Article

Identical twins who are discordant for Leber's hereditary optic neuropathy.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 1993

Johns D R, Smith K H, Miller N R, Sulewski M E, Bias W B

Abstract excerpt

OBJECTIVE: Leber's hereditary optic neuropathy is a maternally inherited form of visual loss that is associated with several mitochondrial DNA mutations. These mitochondrial DNA mutations are not the sole determinants of visual loss, as epigenetic factors may play a pathogenetic role. To clarify the role of these factors, we studied two visually discordant twins and determined their zygosity and mitochondrial...

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PMID: 8240103
DOI: 10.1001/archopht.1993.01090110057023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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