Article
Identical twins who are discordant for Leber's hereditary optic neuropathy.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 1993
Johns D R, Smith K H, Miller N R, Sulewski M E, Bias W B
Abstract excerpt
OBJECTIVE: Leber's hereditary optic neuropathy is a maternally inherited form of visual loss that is associated with several mitochondrial DNA mutations. These mitochondrial DNA mutations are not the sole determinants of visual loss, as epigenetic factors may play a pathogenetic role. To clarify...
Topics
- Adult
- Base Sequence
- Blood Group Antigens
- DNA Mutational Analysis
- DNA, Mitochondrial
- Diseases in Twins
- Genotype
- HLA Antigens
- Humans
- Male
- Molecular Sequence Data
- Optic Atrophies, Hereditary
- Pedigree
- Polymerase Chain Reaction
- Twins, Monozygotic
- Visual Acuity