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Article

Leber hereditary optic neuropathy.

Journal of medical genetics - 1 Mar 2002

Yu-Wai-Man P, Turnbull D M, Chinnery P F

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is a mitochondrial genetic disease that preferentially causes blindness in young adult males, affecting about 1 in 25 000 of the British population. It is characterised by bilateral subacute loss of central vision owing to focal degeneration of the retinal ganglion cell layer and optic nerve. Over 95% of LHON cases are primarily the result of one of three mitochondrial DNA...

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Identifiers

PMID: 11897814
DOI: 10.1136/jmg.39.3.162
PMCID: PMC1735056

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