Mitochondrial DNA Variation of Leber's Hereditary Optic Neuropathy in Western Siberia.

doi:10.3390/cells8121574

Article

Mitochondrial DNA Variation of Leber's Hereditary Optic Neuropathy in Western Siberia.

Cells - 4 Dec 2019

Starikovskaya Elena, Shalaurova Sofia, Dryomov Stanislav, Nazhmidenova Azhar, Volodko Natalia, Bychkov Igor, Mazunin Ilia, Sukernik Rem

Abstract excerpt

Our data first represent the variety of Leber's hereditary optic neuropathy (LHON) mutations in Western Siberia. LHON is a disorder caused by pathogenic mutations in mitochondrial DNA (mtDNA), inherited maternally and presents mainly in young adults, predominantly males. Clinically, LHON manifest...

Topics

Adult
DNA, Mitochondrial
Female
Humans
Male
Mutation
Optic Atrophy, Hereditary, Leber
Polymorphism, Single Nucleotide
Siberia

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