Lack of differences among mitochondrial DNA in family members with Leber's hereditary optic neuropathy and differing visual outcomes.

doi:10.3109/01658109509044589

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Article

Lack of differences among mitochondrial DNA in family members with Leber's hereditary optic neuropathy and differing visual outcomes.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 1 Mar 1995

Mashima Y, Hiida Y, Oguchi Y

Abstract excerpt

Investigation of a maternal family of three generations of Leber's hereditary optic neuropathy (LHON) showed four affected and three unaffected individuals. Two of the four patients had recovered near-normal vision, one spontaneously, and one following treatment with idebenone, a quinol compound. One patient whose visual impairment persisted was a heavy consumer of alcohol and tobacco. Molecular genetic analysis...

Topics

Adult
Aged
Alcohol Drinking
Benzoquinones
Child
DNA, Mitochondrial
Female
Humans
Male
Middle Aged
Mutation
Optic Atrophies, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Prognosis

Smoking

Ubiquinone

Vision Disorders

Visual Acuity

Source

Open in PubMed

Identifiers

PMID: 7780566
DOI: 10.3109/01658109509044589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7780566-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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