Article
Unbiased analysis of the frequency of beta-thalassemia point mutations in a population of African-American newborns.
Archives of pathology & laboratory medicine - 1 Nov 1993
Sylvester-Jackson D A, Page S L, White J M, McCabe H M, Zhang Y H, Therrell B L, McCabe E R
Abstract excerpt
OBJECTIVE: To determine frequency of specific beta-thalassemia alleles in the African-American population prospectively, using newborn screening specimens, and to evaluate the need for including these alleles in screening follow-up programs. DESIGN: Allele-specific oligonucleotide tests were developed and used to analyze African-American newborn screening specimens for beta-thalassemia point mutations to...
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