Article
Unbiased analysis of the frequency of beta-thalassemia point mutations in a population of African-American newborns.
Archives of pathology & laboratory medicine - 1 Nov 1993
Sylvester-Jackson D A, Page S L, White J M, McCabe H M, Zhang Y H, Therrell B L, McCabe E R
Abstract excerpt
OBJECTIVE: To determine frequency of specific beta-thalassemia alleles in the African-American population prospectively, using newborn screening specimens, and to evaluate the need for including these alleles in screening follow-up programs. DESIGN: Allele-specific oligonucleotide tests were developed and used to analyze African-American newborn screening specimens for beta-thalassemia point mutations to...
Topics
- Alleles
- Base Sequence
- Bias
- Black People
- DNA
- Humans
- Infant, Newborn
- Molecular Sequence Data
- Neonatal Screening
- Nucleic Acid Hybridization
- Point Mutation