Article
Unverricht-Lundborg disease: absence of nonallelic genetic heterogeneity.
Annals of neurology - 1 Nov 1993
Cochius J I, Figlewicz D A, Kälviäinen R, Nousiainen U, Farrell K, Patry G, Söderfeldt B, Frydman M, Lerman P, Andermann F
Abstract excerpt
Unverricht-Lundborg disease is a clinically recognizable form of progressive myoclonus epilepsy. Recently, in several families of both Finnish and Mediterranean extraction segregating Unverricht-Lundborg disease, the gene for this disease was linked to the same region of the long arm of chromosome 21. We performed linkage analysis in eight families, including four of neither Baltic nor Mediterranean origin, using...
Topics
- Adolescent
- Child
- Chromosomes, Human, Pair 21
- Epilepsies, Myoclonic
- Family
- Female
- Finland
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans