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Article

Exclusion of linkage between hypokalemic periodic paralysis (HOKPP) and three candidate loci.

Genomics - 1 Oct 1992

Casley W L, Allon M, Cousin H K, Ting S S, Crackower M A, Hashimoto L, Cornélis F, Beckmann J S, Hudson A J, Ebers G C

Abstract excerpt

Hypokalemic periodic paralysis (HOKPP) is an autosomal dominant neuromuscular disorder characterized by flaccid paralysis accompanied by lowered serum potassium levels. We have tested polymorphic markers linked to the adult skeletal muscle sodium channel (SCN4A) locus at 17q23-q25, the T-cell receptor beta (TCRB) locus at 7q35, and the H-Ras cellular proton-cogene locus (HRAS) at 11p15.5 for linkage with the...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Genetic Linkage
Humans
Hypokalemia
Muscles
Paralyses, Familial Periodic
Phenotype
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Channels

Source

Identifiers

PMID: 1330884
DOI: 10.1016/s0888-7543(05)80249-6

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1330884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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