Article
Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions.
Science (New York, N.Y.) - 19 Nov 1993
Zou Y R, Gu H, Rajewsky K
Abstract excerpt
Humanized antibodies are highly efficient as immunotherapeutic reagents and have many advantages over rodent antibodies. A mouse strain was generated by gene targeting to replace the mouse kappa light chain constant (C) region gene with the human C kappa gene. Mice homozygous for the replacement mutation (C kappa R) produced normal concentrations of serum antibodies, most of which carry chimeric kappa light...
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