Article
Enhancement of genetic instability in human B cells by Epstein-Barr virus latent infection.
Mutagenesis - 1 May 2001
Gualandi G, Giselico L, Carloni M, Palitti F, Mosesso P, Alfonsi A M
Abstract excerpt
The level of genetic instability, as assessed by micronucleus (MN) formation, was higher in Epstein-Barr virus (EBV)-converted B-cell lines with one copy of the EBV genome integrated in each cell than in the parental, EBV-negative, B lymphoma cells. MN induced by EBV latency, as analysed by in situ hybridization, contained mainly centromeric regions, indicating that the presence of EBV affects the segregation of...
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