Regional Heterogeneity in the Proliferative Activity of Human Gliomas as Measured by the Ki-67 Labeling Index

Abstract excerpt

The effects of regional heterogeneity on the accuracy of histological grading of gliomas are well known, but little has been reported about its implications for other diagnostic modalities. This study investigated the relationships of regional heterogeneity in tumor proliferative activity, measured by Ki-67 labeling indices (LI), and histological grades for 16 regionally sampled glioma resections. There was a...

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