Article
Antibodies specific for gp40 inhibit cell-cell adhesion by cross-linking the protein on the surface of Dictyostelium purpureum.
Journal of cellular biochemistry - 1 Oct 1993
Springer W R, Haywood-Reid P L
Abstract excerpt
We have previously suggested a role for gp40 in cell-cell adhesion in Dictyostelium purpureum from the fact that antibodies specific for this protein inhibited adhesion in an in vitro assay [Springer: Dev Biol 133:447-455, 1989]. To further confirm the role mutants lacking the protein were isolated and characterized. To our surprise, the mutants had normal adhesive properties both in vitro and in situ. These...
Topics
- Animals
- Antibodies, Fungal
- Cell Adhesion
- Cell Membrane
- Cross-Linking Reagents
- Dictyostelium
- Glycoproteins
- Immunoglobulin G
- Microscopy, Immunoelectron
- Mutation