Article
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies.
PloS one - 13 Jun 2007
Muñoz-Alarcón Andrés, Pavlovic Maja, Wismar Jasmine, Schmitt Bertram, Eriksson Maria, Kylsten Per, Dushay Mitchell S
Abstract excerpt
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are expressed in differentiating cells, while B-type lamins are expressed ubiquitously. Drosophila has two lamin genes that are expressed in A- and B-type patterns, and it is assumed that similarly...
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