Article
Crooked neck dwarf (cn) mutant chicken skeletal muscle cells in low density primary cultures fail to express normal alpha ryanodine receptor and exhibit a partial mutant phenotype.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1993
Airey J A, Deerinck T J, Ellisman M H, Houenou L J, Ivanenko A, Kenyon J L, McKemy D D, Sutko J L
Abstract excerpt
The Crooked Neck Dwarf (cn) mutation in chickens causes marked changes in intact embryonic skeletal muscle. We have investigated whether the cn/cn phenotype develops in vitro, and if cultured muscle cells are suitable for studies of this mutation. The properties of cn/cn muscle cells maintained i...
Topics
- Animals
- Calcium
- Calcium Channels
- Cells, Cultured
- Chick Embryo
- Dwarfism
- Electrophysiology
- Muscle Proteins
- Muscles
- Mutation
- Phenotype
- Poultry Diseases
- Ryanodine Receptor Calcium Release Channel
- Sarcoplasmic Reticulum