Article
Failure to make normal alpha ryanodine receptor is an early event associated with the crooked neck dwarf (cn) mutation in chicken.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 1993
Airey J A, Baring M D, Beck C F, Chelliah Y, Deerinck T J, Ellisman M H, Houenou L J, McKemy D D, Sutko J L, Talvenheimo J
Abstract excerpt
We have investigated the molecular basis of the Crooked Neck Dwarf (cn) mutation in embryonic chickens. Using biochemical and pharmacological techniques we are unable to detect normal alpha ryanodine receptor (RyR) protein in intact cn/cn skeletal muscle. Extremely low levels of alpha RyR immunor...
Topics
- Animals
- Calcium Channels
- Calcium Channels, L-Type
- Calcium-Transporting ATPases
- Calsequestrin
- Chick Embryo
- Dwarfism
- Muscle Proteins
- Muscles
- Mutation
- Myocardium
- Phenotype
- Poultry Diseases
- Purkinje Cells