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Article

Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity.

Biochemical and biophysical research communications - 15 Oct 1993

Ris-Stalpers C, Verleun-Mooijman M C, Trapman J, Brinkmann A O

Abstract excerpt

The human androgen receptor gene in the androgen sensitive prostate tumor cell line (LNCaP) contains a point mutation in codon 868 resulting in the substitution of threonine by alanine. This amino acid change is responsible for the increased affinity of the mutant receptor protein for progestagens and estrogens. To further elucidate the role of threonine 868 on androgen binding capacity, specificity and...

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Identifiers

PMID: 8216289
DOI: 10.1006/bbrc.1993.2231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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