Article
Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity.
Biochemical and biophysical research communications - 15 Oct 1993
Ris-Stalpers C, Verleun-Mooijman M C, Trapman J, Brinkmann A O
Abstract excerpt
The human androgen receptor gene in the androgen sensitive prostate tumor cell line (LNCaP) contains a point mutation in codon 868 resulting in the substitution of threonine by alanine. This amino acid change is responsible for the increased affinity of the mutant receptor protein for progestagen...
Topics
- Amino Acid Sequence
- Androgens
- Animals
- Base Sequence
- Cells, Cultured
- Estradiol
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Metribolone
- Molecular Sequence Data
- Mutation
- Promegestone
- Receptors, Androgen
- Sequence Homology, Amino Acid
- Threonine
- Transcription, Genetic