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Article

Structural Evidence for Ligand Specificity in the Binding Domain of the Human Androgen Receptor

1 Aug 2000

Abstract excerpt

The crystal structures of the human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with the same ligand metribolone (R1881) have been determined. Both three-dimensional structures show the typical nuclear receptor fold. The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR is most likely the source for the specificity of...

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PMID: 10840043
DOI: 10.1074/jbc.m004571200

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