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Article

Selection of a lysine-resistant CHO-K1 mutant with reduced amino acid transport through multiple systems.

Somatic cell and molecular genetics - 1 Jul 1993

DeBusk W E, Ash J F

Abstract excerpt

High levels of L-lysine were used to select for resistant variants of Chinese hamster ovary (CHO-K1) cells. Surviving colonies were screened for altered lysine transport and two with reduced uptake were picked. Clone CH-Kr, derived from the more severely affected colony, was analyzed in detail. In starved cells the Vmax of lysine uptake in CH-Kr was half that of CHO while Km was unaltered. The intracellular pool...

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Identifiers

PMID: 8211377
DOI: 10.1007/BF01232746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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