Article
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Scandinavian journal of gastroenterology - 1 Aug 1993
Ranek L, Dalhoff K, Poulsen H E, Brøsen K, Flachs H, Loft S, Wantzin P
Abstract excerpt
To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane h...
Topics
- Adult
- Aged
- Antipyrine
- Chemical and Drug Induced Liver Injury
- Complement C3
- Female
- HLA Antigens
- Halothane
- Humans
- Male
- Mephenytoin
- Metronidazole
- Middle Aged
- Phenotype
- Phenytoin
- Polymorphism, Genetic
- Sparteine