Article
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Scandinavian journal of gastroenterology - 1 Aug 1993
Ranek L, Dalhoff K, Poulsen H E, Brøsen K, Flachs H, Loft S, Wantzin P
Abstract excerpt
To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and...
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