Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene.

doi:10.1159/000227357

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Article

Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene.

Oncology - 1 Jan 2000

Girgert R, Marini P, Janessa A, Bruchelt G, Treuner J, Schweizer P

Abstract excerpt

Mutated ras genes are found in a variety of human tumors. For biological activity the gene product p21 ras needs to be bound to the cell membrane by a farnesyl residue. Treatment of tumor cells with lovastatin reduces the availability of farnesyl pyrophosphate for the modification of the ras prot...

Topics

Acute Disease
Genes, ras
Humans
Leukemia, Myeloid
Lovastatin
Mutation
Neuroblastoma
Proto-Oncogene Proteins p21(ras)
Tumor Cells, Cultured

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