Article
Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.
Molecular carcinogenesis - 1 Jan 1993
Ruch R J, Madhukar B V, Trosko J E, Klaunig J E
Abstract excerpt
The plasma-membrane association and transforming activity of the ras oncoprotein p21 are dependent upon posttranslational farnesylation. Farnesyl synthesis and p21 ras farnesylation are inhibited by hydroxymethylglutaryl-CoA reductase inhibitors such as lovastatin. In this study, we examined whet...
Topics
- Animals
- Cell Communication
- Cell Division
- Cell Membrane
- Cell Transformation, Neoplastic
- Cells, Cultured
- Drug Interactions
- Epithelial Cells
- Genes, ras
- Intercellular Junctions
- Kinetics
- Liver
- Liver Neoplasms, Experimental
- Lovastatin
- Male
- Mevalonic Acid
- Phenotype
- Proto-Oncogene Proteins p21(ras)