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Article

Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX5.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1999

Peijnenburg A, Van Eggermond M J, Gobin S J, Van den Berg R, Godthelp B C, Vossen J M, Van den Elsen P J

Abstract excerpt

MHC class II deficiency or bare lymphocyte syndrome is a severe combined immunodeficiency caused by defects in MHC-specific transcription factors. In the present study, we show that fibroblasts derived from a recently identified bare lymphocyte syndrome patient, SSI, were mutated for RFX5, one of the DNA-binding components of the RFX complex. Despite the lack of functional RFX5 and resulting MHC class...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, MHC Class II

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Source

Identifiers

PMID: 10395672

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX5.PMID 10395672Read ↗

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