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Article

Genetic analysis of 11 beta-hydroxysteroid dehydrogenase.

Steroids - 1 Feb 1994

White P C, Obeid J, Agarwal A K, Tannin G M, Nikkila H

Abstract excerpt

11 beta-Hydroxysteroid dehydrogenase (11 beta-OHSD) catalyzes the interconversion of cortisol and cortisone. This activity is postulated to protect the Type I (mineralocorticoid) receptor from excessive concentrations of cortisol, allowing aldosterone to function as a mineralocorticoid. An enzyme with 11 beta-OHSD activity was isolated from rat liver and the corresponding rat and human cDNA and genomic clones...

Topics

11-beta-Hydroxysteroid Dehydrogenases
Amino Acid Sequence
Animals
Humans
Hydroxysteroid Dehydrogenases
Metabolism, Inborn Errors
Mineralocorticoids
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation

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Identifiers

PMID: 8191538
DOI: 10.1016/0039-128x(94)90086-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8191538-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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