Article
Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.
Steroids - 1 Jan 1997
White P C, Mune T, Rogerson F M, Kayes K M, Agarwal A K
Abstract excerpt
The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11-HSD) is defective. This enzyme converts cortisol to its inactive metabolite, cortisone. The deficiency allows mineralocorticoid receptors to be occupied b...
Topics
- 11-beta-Hydroxysteroid Dehydrogenases
- Alleles
- Animals
- Cloning, Molecular
- DNA, Complementary
- Female
- Humans
- Hydroxysteroid Dehydrogenases
- Hypertension
- Mineralocorticoids
- Mutation
- Placenta
- Pregnancy
- Rats
- Syndrome
- Transcription, Genetic