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Article

Molecular analysis of 11 beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.

Steroids - 1 Jan 1997

White P C, Mune T, Rogerson F M, Kayes K M, Agarwal A K

Abstract excerpt

The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11-HSD) is defective. This enzyme converts cortisol to its inactive metabolite, cortisone. The deficiency allows mineralocorticoid receptors to be occupied by cortisol, because these receptors themselves have similar affinities for cortisol and aldosterone. There are two...

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Identifiers

PMID: 9029720
DOI: 10.1016/s0039-128x(96)00164-x

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