Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.

doi:10.1128/iai.62.6.2609-2613.1994

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Article

Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.

Infection and immunity - 1 Jun 1994

Tummuru M K, Cover T L, Blaser M J

Abstract excerpt

Helicobacter pylori now is recognized as an etiological agent in chronic superficial gastritis and peptic ulcer disease. Although only about 60% of H. pylori isolates produce an immunodominant 128-kDa antigen (CagA; cytotoxin-associated gene product), virtually all H. pylori-infected patients wit...

Topics

Antigens, Bacterial
Bacterial Proteins
Bacterial Toxins
HeLa Cells
Helicobacter pylori
Humans
Mutation
Structure-Activity Relationship

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