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Article

Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.

Journal of clinical pathology - 1 Jan 1995

Crabtree J E, Covacci A, Farmery S M, Xiang Z, Tompkins D S, Perry S, Lindley I J, Rappuoli R

Abstract excerpt

AIMS: To use a range of natural phenotypically variant strains of Helicobacter pylori with disparate CagA and VacA (vacuolating cytotoxin) expression to determine which bacterial factors are more closely associated with epithelial interleukin-8 (IL-8) induction. METHODS: Gastric epithelial cells (AGS and KATO-3) were co-cultured with five H pylori strains which were variously shown to express the cagA gene/CagA...

Topics

Animals
Antigens, Bacterial
Bacterial Proteins
Blotting, Western
Cell Line
Gastric Mucosa
Gene Expression
Helicobacter pylori
Interleukin-8
Phenotype
Polymerase Chain Reaction

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Identifiers

PMID: 7706517
DOI: 10.1136/jcp.48.1.41
PMCID: PMC502260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7706517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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