Article
Anatomy and dynamics of a ligand-binding pathway in myoglobin: the roles of residues 45, 60, 64, and 68.
Biochemistry - 10 May 1994
Lambright D G, Balasubramanian S, Decatur S M, Boxer S G
Abstract excerpt
In order for diatomic ligands to enter and exit myoglobin, there must be substantial displacements of amino acid side chains from their positions in the static X-ray structure. One pathway, involving Arg/Lys45, His64, and Val68, has been studied in greatest detail. In an earlier study (Lambright...
Topics
- Carbon Monoxide
- Humans
- Kinetics
- Ligands
- Mutation
- Myoglobin
- Protein Binding
- Recombinant Proteins
- Spectrum Analysis
- Thermodynamics