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Article

Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.

Journal of virology - 1 Aug 2009

Jiang Changying, Komazin-Meredith Gloria, Tian Wang, Coen Donald M, Hwang Charles B C

Abstract excerpt

The interactions of the herpes simplex virus processivity factor UL42 with the catalytic subunit of the viral polymerase (Pol) and DNA are critical for viral DNA replication. Previous studies, including one showing that substitution of glutamine residue 282 with arginine (Q282R) results in an increase of DNA binding in vitro, have indicated that the positively charged back surface of UL42 interacts with DNA. To...

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Identifiers

PMID: 19474109
DOI: 10.1128/JVI.00193-09
PMCID: PMC2708624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.PMID 19474109Read ↗

Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.Semantic proximity Read ↗

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