Article
Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses.
Journal of the American Academy of Dermatology - 1 May 1994
McGregor J M, Farthing A, Crook T, Yu C C, Dublin E A, Levison D A, MacDonald D M
Abstract excerpt
BACKGROUND: Loss of p53 tumor suppressor function is a critical step in the development of diverse malignancies, including skin cancers in nonimmunosuppressed patients where UV-specific p53 gene mutations have been identified. In tumors associated with human papillomavirus (HPV), such as cervical carcinoma, p53 may be inactivated instead by binding to a viral oncoprotein. OBJECTIVE: Our purpose was to examine the...
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