Article
Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses.
Journal of the American Academy of Dermatology - 1 May 1994
McGregor J M, Farthing A, Crook T, Yu C C, Dublin E A, Levison D A, MacDonald D M
Abstract excerpt
BACKGROUND: Loss of p53 tumor suppressor function is a critical step in the development of diverse malignancies, including skin cancers in nonimmunosuppressed patients where UV-specific p53 gene mutations have been identified. In tumors associated with human papillomavirus (HPV), such as cervical...
Topics
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Cell Nucleus
- DNA, Viral
- Epidermis
- Genes, p53
- Humans
- Keratoacanthoma
- Keratosis
- Kidney Transplantation
- Mutation
- Papillomaviridae
- Papillomavirus Infections
- Polymerase Chain Reaction
- Skin Neoplasms
- Tumor Suppressor Protein p53
- Tumor Virus Infections