[In vitro characterization of S9788, a new modulator of multidrug resistance].

Article

[In vitro characterization of S9788, a new modulator of multidrug resistance].

Bulletin du cancer - 1 Apr 1993

Pérez V, Pierré A, Léonce S, Anstett M, Prost J F, Atassi G

Abstract excerpt

S9788, a new triazinoaminopiperidine derivative, was 250-fold more active than verapamil in sensitizing DC-3F/AD cells to actinomycin D. This multidrug-resistance modulating activity of S9788 was confirmed on DC-3F/AD, P388/ADR-10, P388/VCR-20, KB/A1, K562/R, S1/tMDR, and COLO320DM cells, with re...

Topics

Animals
Antineoplastic Agents
Cell Cycle
Drug Resistance
Drug Screening Assays, Antitumor
Humans
In Vitro Techniques
Mice
Neoplasms
Neoplasms, Experimental
Phenotype
Piperidines
Triazines
Tumor Cells, Cultured
Verapamil

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