Article
[In vitro characterization of S9788, a new modulator of multidrug resistance].
Bulletin du cancer - 1 Apr 1993
Pérez V, Pierré A, Léonce S, Anstett M, Prost J F, Atassi G
Abstract excerpt
S9788, a new triazinoaminopiperidine derivative, was 250-fold more active than verapamil in sensitizing DC-3F/AD cells to actinomycin D. This multidrug-resistance modulating activity of S9788 was confirmed on DC-3F/AD, P388/ADR-10, P388/VCR-20, KB/A1, K562/R, S1/tMDR, and COLO320DM cells, with respect to actinomycin D, doxorubicin, vincristine, vinblastine and etoposide. S9788 is 2-255-fold more active than...
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