Article
A quantitative approach to the loss of heterozygosity in p53 allele on detection of human cervical cancer using a BioImaging Analyzer.
Asia-Oceania journal of obstetrics and gynaecology - 1 Mar 1994
Kinoshita M, Shin S, Hirao T, Aono T
Abstract excerpt
The presence of HPV16 and HPV18 is believed to be responsible for the tumorigenesis of cervical cancer. As not all HPV-infected patients proceed consistently to carcinoma of the uterine cervix, it is important to clarify at the genetic level the mechanism of the disease progression following HPV infection. We recently investigated the loss of heterozygosity (LOH) in p53 gene, using the quantitative Southern...
Topics
- Adult
- Aged
- Alleles
- Base Sequence
- DNA Probes
- Female
- Genes, p53
- Heterozygote
- Humans
- Middle Aged
- Molecular Sequence Data
- Nucleic Acid Hybridization