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Article

Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits

1 May 1994

Abstract excerpt

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis. For instance, mutant 11D2 (sar::Tn917LTV1) was found to bind substantially less to matrix proteins (i.e., fibrinogen and fibronectin) than parent strain DB. Remarkably, these two strains did not differ in other...

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PMID: 8168933
DOI: 10.1128/iai.62.5.1719-1725.1994

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Related research

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Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbitsPMID 8168933Read ↗

Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis.Semantic proximity Read ↗

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The abilities of a Staphylococcus epidermidis wild-type strain and its slime-negative mutant to induce endocarditis in rabbits are comparable.Semantic proximity Read ↗

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DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.Semantic proximity Read ↗

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