Article
Cloning, mapping and characterization of the Pseudomonas aeruginosa hemL gene.
Molecular & general genetics : MGG - 21 Aug 1995
Hungerer C, Troup B, Römling U, Jahn D
Abstract excerpt
The rate-limiting step in the biosynthesis of tetrapyrroles is the formation of 5-aminolevulinic acid (ALA). In Pseudomonas aeruginosa ALA is synthesized via a two-step reaction from aminoacylated tRNA(Glu) by the action of glutamyl-tRNA reductase and glutamate-1-semialdehyde-2,1-amino mutase. To initiate an investigation of the regulation of the second step in ALA formation, the hemL gene was cloned from P....
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