Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-linked agammaglobulinemia associated with B-precursor acute lymphoblastic leukemia.

Journal of clinical immunology - 1 Feb 2015

Hoshino Akihiro, Okuno Yusuke, Migita Masahiro, Ban Hideki, Yang Xi, Kiyokawa Nobutaka, Adachi Yuichi, Kojima Seiji, Ohara Osamu, Kanegane Hirokazu

Abstract excerpt

X-linked agammaglobulinemia (XLA) is clinically characterized by reduced number of peripheral B cells and diminished levels of serum immunoglobulins, and caused by a mutation in the Bruton's tyrosine kinase (BTK) gene, which play a pivotal role in signal transduction of pre-B-cell receptor (BCR) and BCR. B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in children, and it may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinaemia Tyrosine Kinase
Share to Agammaglobulinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amino Acid Substitution

Share to Genetic Diseases, X-Linked

Share to Immunophenotyping

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Protein-Tyrosine Kinases

Source

Identifiers

PMID: 25591849
DOI: 10.1007/s10875-015-0127-7

Genes

BCR
BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-linked agammaglobulinemia associated with B-precursor acute lymphoblastic leukemia.PMID 25591849Read ↗

Clinical characteristics and genetic profiles of 174 patients with X-linked agammaglobulinemia: Report from Shanghai, China (2000-2015).Semantic proximity Read ↗

X-Linked Agammaglobulinemia A Clinical and Molecular AnalysisSemantic proximity Read ↗

Case Report: Whole exome sequencing identifies a novel frameshift insertion c.1325dupT (p.F442fsX2) in the tyrosine kinase domain of BTK gene in a young Indian individual with X-linked agammaglobulinemiaSemantic proximity Read ↗

Clinical features and mutational analysis of X-linked agammaglobulinemia patients in MalaysiaSemantic proximity Read ↗

Characterization of Bruton's tyrosine kinase mutations in Mexican patients with X-linked agammaglobulinemia.Semantic proximity Read ↗

Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.Semantic proximity Read ↗

Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).Semantic proximity Read ↗

Identification of four novel mutations in BTK from six Chinese families with X-linked agammaglobulinemia.Semantic proximity Read ↗

X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.Semantic proximity Read ↗

Whole Genome Sequencing identifies novel structural variant in a large Indian family affected with X - linked agammaglobulinemiaSemantic proximity Read ↗

Distinct Clinical Features and Novel Mutations in Taiwanese Patients With X-Linked Agammaglobulinemia.Semantic proximity Read ↗

Clinical and genetic findings in two siblings with X-Linked agammaglobulinemia and bronchiolitis obliterans: a case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.