Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors TFIID and TFIIA.

doi:10.1128/JVI.68.5.3298-3307.1994

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Article

Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors TFIID and TFIIA.

Journal of virology - 1 May 1994

Kashanchi F, Shibata R, Ross E K, Brady J N, Martin M A

Abstract excerpt

Second-site revertants from replication-incompetent molecular clones of human immunodeficiency virus (HIV) contain base substitutions adjacent to the TATA motif. The altered TATA box motifs were analyzed for their effect(s) on virus infectivity, long terminal repeat (LTR)-directed expression in transient transfection assays, in vitro RNA synthesis, and assembly of the TFIID-TFIIA preinitiation complex. The...

Topics

Base Sequence
Chloramphenicol O-Acetyltransferase
Gene Products, tat
HIV Long Terminal Repeat
HIV-1
Humans
Macromolecular Substances
Molecular Sequence Data
Mutation
NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

RNA, Viral

Recombinant Fusion Proteins

Sp1 Transcription Factor

TATA Box

Transcription Factor TFIIA

Transcription Factor TFIID

Transcription Factors

Source

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Identifiers

PMID: 8151790
DOI: 10.1128/JVI.68.5.3298-3307.1994
PMCID: PMC236820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8151790-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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